ROLE OF NONI IN ANEURYSM

An aneurysm is an abnormal widening or ballooning of a portion of an artery, related to weakness in the wall of the blood vessel. Some common locations for aneurysms include:

• Aorta (the major artery from the heart) -- see abdominal aortic aneurysm and thoracic aortic aneurysm)

• Brain (cerebral aneurysm)

• Leg (popliteal artery aneurysm)

• Intestine (mesenteric artery aneurysm)

• Splenic artery aneurysm

Causes, incidence, and risk factors
It is not clear exactly what causes aneurysms. Defects in some of the parts of the artery wall may be responsible. In certain cases (abdominal aortic aneurysms), high blood pressure is thought to be a contributing factor. Some aneurysms are congenital (present at birth).
Atherosclerotic disease (cholesterol buildup in arteries) may contribute to the formation of certain types of aneurysms. Pregnancy is often associated with the formation and rupture of aneurysms of the splenic artery (an artery leading to the spleen).

Symptoms
The symptoms vary depending on the location of the aneurysm. Swelling with a throbbing mass at the site of an aneurysm is often seen if it occurs near the body surface. Aneurysms within the body or brain often have no symptoms
In the case of rupture, low blood pressure, high heart rate, and lightheadedness may occur. The risk of death after a rupture is high.

Role of Noni
1. High blood pressure is thought to be a contributing factor of aneurysm.
NONI keeps high blood pressure in check:
The Role of Nitric oxide –
As we are well aware, hypertension has multifactor etiology. It is clear that diet, exercise, and genetics play a role in the human body’s circulatory function.
The level of nitric oxide is believed to be one controller of blood pressure within the body. Noni stimulates and boosts the body’s immune system, therefore enabling the body to produce more nitric oxide in the body. Recent studies have shown how specific extracts from Morinda citrifolia (NONI) produce a significant nitric oxide effect in endothelial cells in vitro. Nitric oxide acts as a vaso dilator to reduce the high blood pressure in hypertensive patient.
The Role of Scopoletin present in Noni to reduce the Hypertension-
Another key component found in Noni that has been connected to lowering blood pressure is scopoletin. Scopoletin, which has been scientifically proven to dilate blood vessels and act as a vaso dilator also helps in lowering the blood pressure.
Role of Xeronine , the alkaloid of Noni in reducing High Blood Pressure and cardiovascular diseases
Xeronine is a small alkaloid that is required in picro gram(trillionth of gram) amounts and is essential to the correct functioning of body. Large amount are used in times of physical or mental stress. In over mental stress condition the blood pressure rises hence the role of xeronine helps in lowering the blood pressure by maintaining the normal function of all cells, enzymes, and keeping all the endocrine system to act in a harmonious way.
The xeronine system promotes a healthy cell structure within the circulatory system thus maintain the blood pressure within the normal range.


The role serotonin in cardiovascular diseases
Serotonin is a neurotransmitter, a specialized molecule that allows nerve cells to communicate and interact with each other. Without neurotransmitters we would be unable to think, perceive, move, or even live. Serotonin also does double duty in the cardiovascular and gastrointestinal systems. It helps regulate the expansion and contraction of blood vessels and the function of platelets, the blood cells that cause blood to coagulate and close a wound. It is synthesized in different parts of the brain and body, where it can be stored or released. The most important raw ingredient is an amino acid called tryptophan. Noni is a good source for tryptophan. When we take Noni the amino acid tryptophan enters ours blood stream and are carried to tissues that will use them to synthesize the body's own proteins and other essential molecules, including serotonin.

2. Defects in some of the parts of the artery wall may be responsible for the formation of aneurysm
If the defect artery tissues are the free radical cause then Noni will help a lot as Noni is an efcetive antioxidant. Noni contain all antioxidant vitamins, all trace minerals, and lots of phyto chemicals. All phytochemicals have powerful antioxidant property. So Noni will help a lot to netralise the free radical damaging efcet over the artery tissues. Besides that Noni also increases the synthesis of antioxidant enzymes in our body . Noni also raise the glutathione level which is a potent antioxidant. Thus Noni protect the artery wall tissue from the oxidative stress injury and prevents the formation of aneurysm.

If the origin of defect of tye artery wall is some other cause then also Noni may help as Noni is rich with nutrients and micronutrients and thus it helps to rejuvinate the cells and also the xeronine alakloid of Noni helps to repair the damage cells. Hence Noni support the artery tissues and prevents it from any damage.

3. Atherosclerotic disease may contribute to the formation of certain types of aneurysms.
Noni prevents the Atherosclerotic changes inside the vessels
The high rise of cholesterol in our blood is one of the causes of atherosclerotic changes inside the vessels. Cholesterol is of two types – HDL (high density lipoprotein) cholesterol and LDL (low density lipoprotein) cholesterol. Among them HDL cholesterol is good for our body. But LDL cholesterol is named as bad cholesterol. . But LDL cholesterol is not really bad in its native form because God did not make a mistake when he created it. Native LDL cholesterol is good. In fact it is essential for building good cell membrane, others cell parts, and many different hormones that our body needs. Problems begin when native LDL cholesterols are oxidized by the free radicals in our body and make them the harmful cholesterol. The high environmental pollutions, our stressful life style, a good nutrients depleted diet are the main causes of over production of free radicals in our body. Those free radicals play the main role to oxidize LDL cholesterol and make it harmful to our body. So to neutralize the notorious activity of those free radicals to convert the native LDL cholesterol to harmful LDL cholesterol it is required some powerful antioxidants. Those antioxidants not only neutralize the effect of free radicals on the vessels cells but also to other cells. NONI have the powerful antioxidant properties that help to neutralize the free radicals role of oxidation of the native LDL cholesterol to harmful LDL cholesterol and thus protects the arterial endothelial lining from injury and future developing atheromatous plaque. The main antioxidants are vitamins A, E and C, beta-carotene, glutathione, bioflavonoid, selenium, zinc, CoQ10 (ubiquinone), and various phyto-chemicals. NONI is rich with Vita A, Beta carotene, Vita E, C, glutathione, bioflavonoid, selenium, zinc, and many more essential phytochemicals. Melatonin, a hormone produced by the pineal gland, is also a potent antioxidant. NONI helps to stimulate more melatonin release from the pineal gland.
Thus Noni prevents the atherosclerotic changes inside the vessels.


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