Noni to prevent Cancer

• Limonene, the phytochemical present in Noni increases the levels of liver enzymes involved in detoxifying carcinogens.

• Cancer chemoprevention involves prevention, delay or reversal of the process of carcinogenesis through ingestion of dietary or pharmaceutical agents. Recent advances which have defined the cellular and molecular events associated with carcinogenesis, along with a growing body of experimental, epidemiological and clinical trial data, provide a foundation for relatively new startegies of cancer prevention. One such strategy involves suppression of carcinogen metabolic activation or blocking the formation of ultimate carcinogens. In particular, the induction of phase II enzymes offers protection against toxic and reactive chemical species. Many recent studies have shown that elevation of phase II enzymes, such as NAD(P) H : quinone reductase (QR) and GST, correlates with protection against chemical - induced carcinogenesis in animal models, in the stage of promotion as well as initiation. Noni fruits contain an extremely potent quinone reductase inducer, 2 - methoxy - 1,b,6 - trihydroxyanthraquinone. This new anthraquinone was nearly 40 times more potent than all.
Glycosides
• Noni contains many glycosides - Glycosides are compounds containing a carbohydrate and a noncarbohydrate residue in the same molecule. The nonsugar component is known as the AGLYCONE. The sugar component is called the GLYCONE. If the glycone group of a glycoside is glucose, then the molecule is a glucoside; if it is fructose, then the molecule is a fructoside; if its is glucuronic acid, then the molecule is a glucuronide; etc. In the body, toxic substances are often bonded to glucuronic acid to increase their water solubility; the resulting glucuronides are then excreted. Many plants store important chemicals in the form of inactive glycosides; if these chemicals are needed, the glycosides are brought in contact with water and an enzyme, and the sugar part is broken off, making the chemical available for use. Asperuloside is a glycoside. Traditionally, this glycoside is used for diurises (reducing water retention), treating inflammation and varicose veins and phlebitis. Research indicates that it is anticlastogenic (that is, prevents the breakage of chromosomes). As a result, it is anti-mutagenic or resists mutation within the cell’s DNA.

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