Noni on Cancer

• Noni possesses anti tumor activity by stimulating immune factors like TNF, NK cells etc. to attack the tumor. Noni can be used as an immune supplemental therapeutic agent with any cancer theraphy.

• Noni has anti angiogenesis effect on tumor, hence inhibits tumor development.

• Noni prevents DNA adduct formation. Hence protects the cell from converting to cancer. Noni can be used for primary and secondary prevention of cancer.

• In vitro study shows that the Damnacanthal, one phytochemical in Noni has anti-carcinogenic effect.

• Noni ppt = Noni Polysaccharides - This polysaccharide is made up of 4 sugars (glucuronic acid, galactose, arabinose and rhamnose). It has immune modulatory effects.

• The Glutathione S-transferase (GST) is a system which eliminates carcinogens. Limonene in Noni juice promotes the GST system in the liver and small bowel, thereby decreasing damaging effects of carcinogens. Animal studies demonstrated that dietary limonene reduced mammary tumour growth.

• All types of cancer, irrespective of which organ they start in, spread by the same means : they use biological cutting tools (enzymes) capable of cutting through the surrounding collagen connective tissue. Matrix metalloproteinases (MMPs), the enzymes are identified as key players in tumor invasion and metastasis. Excessive MMPs secretion is regarded as an index of malignancy which leads to degradation of extra cellular matrix. Current treatment protocols with chemotherapy and /or radiation although beneficial, are toxic and have the potential to destroy healthy cells as well. Our approach is to develop strategies to inhibit cancer development, progression and metastasis using naturally occurring nutrients, relatively non-toxic. Lysine and proline are building blocks of collagen fibers that stabilize connective tissue by inhibiting the enzymatic digestion of collagen fibers. Vitamin C is essential for production of collagen and acts as a powerful antioxidant by scavenging free radicals and thereby protects cells from damage. Epigallocatechin gallate (EGCG) has antioxidant and anticancerogenic properties. It prevents cancer cell invasion by inhibiting MMPs. The natural amino acid lysine, especially in combination with vitamin C and other selected cellular nutrients, is capable of blocking this ‘collagen digestion’. We have a biological mechanism that prevents the spread of cancer cells - and therefore cancer itself. It is postulated that the combination of these nutrients would exert a very potent synergistic anticancer activity. Noni contains the above two amino acids lysine and praline. Noni is rich in vitamin C. Noni contains the phytochemical Epigallocatehin gallate (EGCG). Hence Noni should help to prevent the cancer tumor invasion and metastasis.

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