particularly acute hepatitis. Noni reduces the production SGPT and SDH in Liver and heart cells. Hence noni has good hepatoprotective function.
Phytochemicals present in Noni : Rutin
Rutin, the phytochemical has also the property to chelate metal ions, such as iron. Hence Noni can be helpful in thalassemia codition.
Rutin also seems to stabilize vitamin C. If rutin is taken together with vitamin C, the activity of ascorbic acid will be intensified.
Rutin is important because it strengthens capillaries and helps people who bruises or bleeds easily. Rutin prevents atherosclerotic plaques inside the arteries and thus has cardio protective function.
Studies demonstrated that rutin stops venous edema, which is an early sign of chronic venous disease of the leg. Hence it helps in varicosity of vein.
Caprylic acid - Caprylic acid is a fatty acid that has antifungal properties.
Scopoletin
Scopoletin exhibits a cholesterol lowering effect and vasodilating properties. Hence it helps in hypertension, hypercholesterolemia and prevention of CAD.
Cyclooxygenase and 5 - lipoxygenase cause inflammation and pain. Scopoletin has demonstrated inhibitory effects on these mediators. Hence Noni has anti inflammatory and analgesic activity.
Scopoletin has anit-spasmolytic activity on the uterus and small intestine, therefore being beneficial in menstrual cramping and irritable bowel conditions.
Scopoletin has bacteriostatic activity against various species of bacteria, including Escherichia coil, Staphylococcus aureus, Streptococcus sp., Klebsiella pneumoniae and Pseudomonas aeruginosa.
Ursolic acid
Ursolic acid has anti fungal property. It inhibits the growth of Candida albicans and Microsporium lenosum. Ursolic acid has anti-inflammatory properties and is used in ointments to treat burns.
for more information on NONI please visit http://www.ideasynergies.com
Wednesday, April 21, 2010
Noni to prevent Cancer
• Limonene, the phytochemical present in Noni increases the levels of liver enzymes involved in detoxifying carcinogens.
• Cancer chemoprevention involves prevention, delay or reversal of the process of carcinogenesis through ingestion of dietary or pharmaceutical agents. Recent advances which have defined the cellular and molecular events associated with carcinogenesis, along with a growing body of experimental, epidemiological and clinical trial data, provide a foundation for relatively new startegies of cancer prevention. One such strategy involves suppression of carcinogen metabolic activation or blocking the formation of ultimate carcinogens. In particular, the induction of phase II enzymes offers protection against toxic and reactive chemical species. Many recent studies have shown that elevation of phase II enzymes, such as NAD(P) H : quinone reductase (QR) and GST, correlates with protection against chemical - induced carcinogenesis in animal models, in the stage of promotion as well as initiation. Noni fruits contain an extremely potent quinone reductase inducer, 2 - methoxy - 1,b,6 - trihydroxyanthraquinone. This new anthraquinone was nearly 40 times more potent than all.
Glycosides
• Noni contains many glycosides - Glycosides are compounds containing a carbohydrate and a noncarbohydrate residue in the same molecule. The nonsugar component is known as the AGLYCONE. The sugar component is called the GLYCONE. If the glycone group of a glycoside is glucose, then the molecule is a glucoside; if it is fructose, then the molecule is a fructoside; if its is glucuronic acid, then the molecule is a glucuronide; etc. In the body, toxic substances are often bonded to glucuronic acid to increase their water solubility; the resulting glucuronides are then excreted. Many plants store important chemicals in the form of inactive glycosides; if these chemicals are needed, the glycosides are brought in contact with water and an enzyme, and the sugar part is broken off, making the chemical available for use. Asperuloside is a glycoside. Traditionally, this glycoside is used for diurises (reducing water retention), treating inflammation and varicose veins and phlebitis. Research indicates that it is anticlastogenic (that is, prevents the breakage of chromosomes). As a result, it is anti-mutagenic or resists mutation within the cell’s DNA.
for more information on NONI please visit http://www.ideasynergies.com
• Cancer chemoprevention involves prevention, delay or reversal of the process of carcinogenesis through ingestion of dietary or pharmaceutical agents. Recent advances which have defined the cellular and molecular events associated with carcinogenesis, along with a growing body of experimental, epidemiological and clinical trial data, provide a foundation for relatively new startegies of cancer prevention. One such strategy involves suppression of carcinogen metabolic activation or blocking the formation of ultimate carcinogens. In particular, the induction of phase II enzymes offers protection against toxic and reactive chemical species. Many recent studies have shown that elevation of phase II enzymes, such as NAD(P) H : quinone reductase (QR) and GST, correlates with protection against chemical - induced carcinogenesis in animal models, in the stage of promotion as well as initiation. Noni fruits contain an extremely potent quinone reductase inducer, 2 - methoxy - 1,b,6 - trihydroxyanthraquinone. This new anthraquinone was nearly 40 times more potent than all.
Glycosides
• Noni contains many glycosides - Glycosides are compounds containing a carbohydrate and a noncarbohydrate residue in the same molecule. The nonsugar component is known as the AGLYCONE. The sugar component is called the GLYCONE. If the glycone group of a glycoside is glucose, then the molecule is a glucoside; if it is fructose, then the molecule is a fructoside; if its is glucuronic acid, then the molecule is a glucuronide; etc. In the body, toxic substances are often bonded to glucuronic acid to increase their water solubility; the resulting glucuronides are then excreted. Many plants store important chemicals in the form of inactive glycosides; if these chemicals are needed, the glycosides are brought in contact with water and an enzyme, and the sugar part is broken off, making the chemical available for use. Asperuloside is a glycoside. Traditionally, this glycoside is used for diurises (reducing water retention), treating inflammation and varicose veins and phlebitis. Research indicates that it is anticlastogenic (that is, prevents the breakage of chromosomes). As a result, it is anti-mutagenic or resists mutation within the cell’s DNA.
for more information on NONI please visit http://www.ideasynergies.com
Noni on Cancer
• Noni possesses anti tumor activity by stimulating immune factors like TNF, NK cells etc. to attack the tumor. Noni can be used as an immune supplemental therapeutic agent with any cancer theraphy.
• Noni has anti angiogenesis effect on tumor, hence inhibits tumor development.
• Noni prevents DNA adduct formation. Hence protects the cell from converting to cancer. Noni can be used for primary and secondary prevention of cancer.
• In vitro study shows that the Damnacanthal, one phytochemical in Noni has anti-carcinogenic effect.
• Noni ppt = Noni Polysaccharides - This polysaccharide is made up of 4 sugars (glucuronic acid, galactose, arabinose and rhamnose). It has immune modulatory effects.
• The Glutathione S-transferase (GST) is a system which eliminates carcinogens. Limonene in Noni juice promotes the GST system in the liver and small bowel, thereby decreasing damaging effects of carcinogens. Animal studies demonstrated that dietary limonene reduced mammary tumour growth.
• All types of cancer, irrespective of which organ they start in, spread by the same means : they use biological cutting tools (enzymes) capable of cutting through the surrounding collagen connective tissue. Matrix metalloproteinases (MMPs), the enzymes are identified as key players in tumor invasion and metastasis. Excessive MMPs secretion is regarded as an index of malignancy which leads to degradation of extra cellular matrix. Current treatment protocols with chemotherapy and /or radiation although beneficial, are toxic and have the potential to destroy healthy cells as well. Our approach is to develop strategies to inhibit cancer development, progression and metastasis using naturally occurring nutrients, relatively non-toxic. Lysine and proline are building blocks of collagen fibers that stabilize connective tissue by inhibiting the enzymatic digestion of collagen fibers. Vitamin C is essential for production of collagen and acts as a powerful antioxidant by scavenging free radicals and thereby protects cells from damage. Epigallocatechin gallate (EGCG) has antioxidant and anticancerogenic properties. It prevents cancer cell invasion by inhibiting MMPs. The natural amino acid lysine, especially in combination with vitamin C and other selected cellular nutrients, is capable of blocking this ‘collagen digestion’. We have a biological mechanism that prevents the spread of cancer cells - and therefore cancer itself. It is postulated that the combination of these nutrients would exert a very potent synergistic anticancer activity. Noni contains the above two amino acids lysine and praline. Noni is rich in vitamin C. Noni contains the phytochemical Epigallocatehin gallate (EGCG). Hence Noni should help to prevent the cancer tumor invasion and metastasis.
for more detail please visit http://www.ideasynergies.com
• Noni has anti angiogenesis effect on tumor, hence inhibits tumor development.
• Noni prevents DNA adduct formation. Hence protects the cell from converting to cancer. Noni can be used for primary and secondary prevention of cancer.
• In vitro study shows that the Damnacanthal, one phytochemical in Noni has anti-carcinogenic effect.
• Noni ppt = Noni Polysaccharides - This polysaccharide is made up of 4 sugars (glucuronic acid, galactose, arabinose and rhamnose). It has immune modulatory effects.
• The Glutathione S-transferase (GST) is a system which eliminates carcinogens. Limonene in Noni juice promotes the GST system in the liver and small bowel, thereby decreasing damaging effects of carcinogens. Animal studies demonstrated that dietary limonene reduced mammary tumour growth.
• All types of cancer, irrespective of which organ they start in, spread by the same means : they use biological cutting tools (enzymes) capable of cutting through the surrounding collagen connective tissue. Matrix metalloproteinases (MMPs), the enzymes are identified as key players in tumor invasion and metastasis. Excessive MMPs secretion is regarded as an index of malignancy which leads to degradation of extra cellular matrix. Current treatment protocols with chemotherapy and /or radiation although beneficial, are toxic and have the potential to destroy healthy cells as well. Our approach is to develop strategies to inhibit cancer development, progression and metastasis using naturally occurring nutrients, relatively non-toxic. Lysine and proline are building blocks of collagen fibers that stabilize connective tissue by inhibiting the enzymatic digestion of collagen fibers. Vitamin C is essential for production of collagen and acts as a powerful antioxidant by scavenging free radicals and thereby protects cells from damage. Epigallocatechin gallate (EGCG) has antioxidant and anticancerogenic properties. It prevents cancer cell invasion by inhibiting MMPs. The natural amino acid lysine, especially in combination with vitamin C and other selected cellular nutrients, is capable of blocking this ‘collagen digestion’. We have a biological mechanism that prevents the spread of cancer cells - and therefore cancer itself. It is postulated that the combination of these nutrients would exert a very potent synergistic anticancer activity. Noni contains the above two amino acids lysine and praline. Noni is rich in vitamin C. Noni contains the phytochemical Epigallocatehin gallate (EGCG). Hence Noni should help to prevent the cancer tumor invasion and metastasis.
for more detail please visit http://www.ideasynergies.com
Sunday, April 18, 2010
Additonal Role of NONI in case Acne
Role of Noni
Skin healing:
Noni contain lipoic acid, betacarotene, protein, and vitamins A, C, and E. These ingredients reportedly repair damaged tissue and mitigate free-radical damage and thus helps in the healing process in acne
Cleansers: Noni acts like a good cleanser. Noni detoxify our body.
Antibacterial/anti fungal:
Noni for acne can help reduce inflammation, and infection. Acubin, L-asperuloside, and alizarin in the Noni have antibacterial activity as well as some other ingredients anthraquinone compounds are also proven antibacterial agents
Astringents: Noni acts like an effective astringents and remove excess facial oil.
for deatiled information please visit http://www.ideasynergies.com
Skin healing:
Noni contain lipoic acid, betacarotene, protein, and vitamins A, C, and E. These ingredients reportedly repair damaged tissue and mitigate free-radical damage and thus helps in the healing process in acne
Cleansers: Noni acts like a good cleanser. Noni detoxify our body.
Antibacterial/anti fungal:
Noni for acne can help reduce inflammation, and infection. Acubin, L-asperuloside, and alizarin in the Noni have antibacterial activity as well as some other ingredients anthraquinone compounds are also proven antibacterial agents
Astringents: Noni acts like an effective astringents and remove excess facial oil.
for deatiled information please visit http://www.ideasynergies.com
Role of Noni on Acne
Noni for acne can help reduce inflammation, and infection. Acubin, L-asperuloside, and alizarin present in the Noni have the antibacterial activity. Other ingredients anthraquinone compounds are also proven antibacterial agents. These compounds have been shown to fight against infectious bacteria strains such as Pseudomonas aeruginosa, Proteus morgaii, Staphylococcus aureus, Baciillis subtilis, Escherichia coli, Salmonella, and Shigela.
Vitamins A and E. The benefits of vitamins A and E in acne was highlighted in a recent study in which investigators identified plasma vitamin A and E concentrations in 100 untreated patients with acne, compared with 100 healthy controls. Plasma concentrations of both vitamins in patients with acne were significantly lower than those of the controls, and a strong relationship between a decline in vitamin A and E levels and an increase in the severity of acne was noted (El-Akawi Z et al 2006). Noni contain abundant quantity of Vitamin A and E thus may help a lot in Acne cases
Lipoic acid. Research into the efficacy of lipoic acid in the treatment of acne goes back several decades. Reportedly, lipoic acid activates a factor in the body known as AP-1, which produces enzymes that digest damaged collagen and helps erase scars, including acne scars (Kovalev VM 1981a,b). Lipoic acid is an ingredient in several topical acne remedies. Noni contains the Lipoic acid in natural form
Zinc. This mineral appears to perform a threefold role in the treatment of acne. It helps reduce inflammation; kills Propionibacterium acnes, the main bacteria associated with the disease, and produces changes in the skin environment that make it more hostile to this bacterium for a longer time. In a double-blind study, a combination of 1.2 percent zinc and 4 percent erythromycin in a topical lotion was used by 14 individuals with acne. The combination significantly reduced secretion of sebum after six weeks of treatment. Noni contain this essential rare mineral and thus helps in Acne cases.
Essential Fatty Acids. The omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are well-known anti-inflammatories that have been shown in some studies to reduce inflammation. Several studies have found that omega-3 fatty acids are absorbed through the skin and can reduce inflammation in a particular area .
Noni contains all the essential fatty acids and thus helps in case of Acne.
for deatiled information please visit http://www.ideasynergies.com
Vitamins A and E. The benefits of vitamins A and E in acne was highlighted in a recent study in which investigators identified plasma vitamin A and E concentrations in 100 untreated patients with acne, compared with 100 healthy controls. Plasma concentrations of both vitamins in patients with acne were significantly lower than those of the controls, and a strong relationship between a decline in vitamin A and E levels and an increase in the severity of acne was noted (El-Akawi Z et al 2006). Noni contain abundant quantity of Vitamin A and E thus may help a lot in Acne cases
Lipoic acid. Research into the efficacy of lipoic acid in the treatment of acne goes back several decades. Reportedly, lipoic acid activates a factor in the body known as AP-1, which produces enzymes that digest damaged collagen and helps erase scars, including acne scars (Kovalev VM 1981a,b). Lipoic acid is an ingredient in several topical acne remedies. Noni contains the Lipoic acid in natural form
Zinc. This mineral appears to perform a threefold role in the treatment of acne. It helps reduce inflammation; kills Propionibacterium acnes, the main bacteria associated with the disease, and produces changes in the skin environment that make it more hostile to this bacterium for a longer time. In a double-blind study, a combination of 1.2 percent zinc and 4 percent erythromycin in a topical lotion was used by 14 individuals with acne. The combination significantly reduced secretion of sebum after six weeks of treatment. Noni contain this essential rare mineral and thus helps in Acne cases.
Essential Fatty Acids. The omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are well-known anti-inflammatories that have been shown in some studies to reduce inflammation. Several studies have found that omega-3 fatty acids are absorbed through the skin and can reduce inflammation in a particular area .
Noni contains all the essential fatty acids and thus helps in case of Acne.
for deatiled information please visit http://www.ideasynergies.com
Types of Acne Lesions
• Open comedones (blackheads): These are dilated hair follicles that are filled with sebum, dead cells and bacteria, and which have central, dark, solid plugs. The follicles are not completely blocked; the black appearance is caused by oxidation, not dirt.
• Closed comedones (whiteheads): These form when skin cells and oil completely block the opening of a hair follicle, usually after a blackhead has formed.
• Nodules: These are solid, dome- or irregularly shaped, inflamed lesions that extend deep into the skin, sometimes causing tissue damage and scarring if not treated. Nodular acne, which can be painful, is the most severe form of the disease.
• Papules: This type of whitehead (5 mm or less) is one that has become swollen, red and inflamed
• Cysts: These sac-like lesions contain white blood cells, bacteria and dead cells in a liquid or semi-liquid state. They can result in scarring, and may be very painful and severely inflamed. Cysts and nodules often appear together to form nodulocystic acne, also very severe.
• Pustules: This whitehead is pus-filled and inflamed. Once they rupture into the skin, they form pustular heads.
Acne can be caused by environmental and genetic factors. The role of hormones in the development of acne is apparent at puberty, when there is a surge in the production of male hormones (which are present in both males and females), enlarging the sebaceous glands in the skin. This results in increased sebum production, which leads to the aforementioned plug formation, creating as well a fertile environment in which bacteria can multiple. Unlike male-hormone androgens, female-hormone estrogens have a beneficial effect on acne, which is why some doctors recommend birth control pills for women who have acne. But when a woman’s estrogen levels decline, as they do just before the beginning of a menstrual cycle, acne may worsen.
Acne or acne-like lesions can develop in response to various substances, including corticosteroids, lithium, and some psychotropic drugs. Use of many types of cosmetics, oil-based hair products, and suntan lotions can block oil glands and worsen acne.
for deatiled information please visit http://www.ideasynergies.com
• Closed comedones (whiteheads): These form when skin cells and oil completely block the opening of a hair follicle, usually after a blackhead has formed.
• Nodules: These are solid, dome- or irregularly shaped, inflamed lesions that extend deep into the skin, sometimes causing tissue damage and scarring if not treated. Nodular acne, which can be painful, is the most severe form of the disease.
• Papules: This type of whitehead (5 mm or less) is one that has become swollen, red and inflamed
• Cysts: These sac-like lesions contain white blood cells, bacteria and dead cells in a liquid or semi-liquid state. They can result in scarring, and may be very painful and severely inflamed. Cysts and nodules often appear together to form nodulocystic acne, also very severe.
• Pustules: This whitehead is pus-filled and inflamed. Once they rupture into the skin, they form pustular heads.
Acne can be caused by environmental and genetic factors. The role of hormones in the development of acne is apparent at puberty, when there is a surge in the production of male hormones (which are present in both males and females), enlarging the sebaceous glands in the skin. This results in increased sebum production, which leads to the aforementioned plug formation, creating as well a fertile environment in which bacteria can multiple. Unlike male-hormone androgens, female-hormone estrogens have a beneficial effect on acne, which is why some doctors recommend birth control pills for women who have acne. But when a woman’s estrogen levels decline, as they do just before the beginning of a menstrual cycle, acne may worsen.
Acne or acne-like lesions can develop in response to various substances, including corticosteroids, lithium, and some psychotropic drugs. Use of many types of cosmetics, oil-based hair products, and suntan lotions can block oil glands and worsen acne.
for deatiled information please visit http://www.ideasynergies.com
Noni on Acne Treatment
Acne (acne vulgaris) is a dermatologic condition characterized by lesions that most often appear on the face and neck, but also develop on the chest, back, shoulders and upper arms. Approximately 80 percent to 95 percent of adolescents develop some degree of acne. Acne is characterized by pimples, cysts and abscesses. It occurs when the pores in the skin are blocked, trapping oil, dead skin and bacteria in the hair follicles. Under normal circumstances, glands (called sebaceous glands) attached to hair follicles secrete an oily substance known as sebum. This sebum typically travels up the hair follicle and onto the skin. However, if the hair follicle is blocked, the sebum can’t get out, sometimes causing the formation of a blackhead. This is the result of the blocked oil oxidizing, causing inflammation and an influx of white blood cells. Meanwhile, normally present bacteria (Propionibacterium acnes) begin to break down the trapped sebum within the hair follicle. This results in further inflammation, as white blood cells attack the bacteria. Pus forms as the lesion enters the whitehead stage. In more severe stages, an abscess—a pus-filled pocket within the skin—may form. Although most pimples won’t leave lasting scars, anything that damages the dermis (the layer of skin just underneath the epidermis) can leave a permanent scar.
for deatiled information please visit http://www.ideasynergies.com
for deatiled information please visit http://www.ideasynergies.com
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